Version 5.4
Mus musculus Protein: Bpgm
Summary
InnateDB Protein IDBP-134822.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bpgm
Protein Name 2,3-bisphosphoglycerate mutase
Synonyms AI323730; AL022789; C86192;
Species Mus musculus
Ensembl Protein ENSMUSP00000047393
InnateDB Gene IDBG-134820 (Bpgm)
Protein Structure
UniProt Annotation
Function Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in red blood cells. Expressed in placenta (labyrinthine trophoblasts). {ECO:0000269PubMed:19733906, ECO:0000269PubMed:2847721}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004082 bisphosphoglycerate mutase activity
GO:0004083 bisphosphoglycerate 2-phosphatase activity
GO:0004619 phosphoglycerate mutase activity
GO:0016868 intramolecular transferase activity, phosphotransferases
Biological Process
GO:0006096 glycolytic process
GO:0016311 dephosphorylation
GO:0048821 erythrocyte development
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:1098242
InterPro IPR005952 Phosphoglycerate mutase 1
IPR013078 Histidine phosphatase superfamily, clade-1
IPR029033 Histidine phosphatase superfamily
PFAM PF00300
PRINTS
PIRSF
SMART SM00855
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P15327
PhosphoSite PhosphoSite-P15327
TrEMBL D3Z223
UniProt Splice Variant
Entrez Gene 12183
UniGene Mm.440661
RefSeq NP_031589
MGI ID
MGI Symbol Bpgm
OMIM
CCDS CCDS19994
HPRD
IMGT
EMBL AC115767 AK043412 AK078119 BC004589 X13586
GenPept AAH04589 BAC31541 BAC37133 CAA31927

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca