Version 5.4
Mus musculus Gene: Bpgm
Summary
InnateDB Gene IDBG-134820.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bpgm
Gene Name 2,3-bisphosphoglycerate mutase
Synonyms AI323730; AL022789; C86192
Species Mus musculus
Ensembl Gene ENSMUSG00000038871
Encoded Proteins
IDBP-134822
2,3-bisphosphoglycerate mutase
IDBP-540640
2,3-bisphosphoglycerate mutase
IDBP-540884
2,3-bisphosphoglycerate mutase
IDBP-538174
2,3-bisphosphoglycerate mutase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172331:
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:34476207-34505613
Strand Forward strand
Band B1
Transcripts
ENSMUST00000045372 ENSMUSP00000047393
ENSMUST00000135743
ENSMUST00000138668 ENSMUSP00000115825
ENSMUST00000139067 ENSMUSP00000120794
ENSMUST00000149131 ENSMUSP00000121818
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004082 bisphosphoglycerate mutase activity
GO:0004083 bisphosphoglycerate 2-phosphatase activity
GO:0004619 phosphoglycerate mutase activity
GO:0016868 intramolecular transferase activity, phosphotransferases
Biological Process
GO:0006096 glycolytic process
GO:0016311 dephosphorylation
GO:0048821 erythrocyte development
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172331
View Gene Order
ENSBTAG00000008895
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00260
Glycine, serine and threonine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00260
Glycine, serine and threonine metabolism pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.282863 Mm.431390 Mm.440661
RefSeq NM_007563
OMIM
CCDS CCDS19994
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca