InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Terf1

Summary

InnateDB Protein

IDBP-134895.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Terf1

Protein Name

telomeric repeat binding factor 1

Synonyms

Pin2; Trbf1; Trf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027057

InnateDB Gene

IDBG-134893 (Terf1)

Protein Structure

UniProt Annotation

Function

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. {ECO:0000269PubMed:24413433}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00625}. Chromosome, telomere {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 276 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	276 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003691	double-stranded telomeric DNA binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008301	DNA binding, bending
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010521	telomerase inhibitor activity
GO:0042162	telomeric DNA binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000723	telomere maintenance
GO:0001309	age-dependent telomere shortening
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0031116	positive regulation of microtubule polymerization
GO:0032211	negative regulation of telomere maintenance via telomerase
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0045840	positive regulation of mitosis
GO:0045931	positive regulation of mitotic cell cycle
GO:0051260	protein homooligomerization
GO:0051974	negative regulation of telomerase activity
GO:1900119	positive regulation of execution phase of apoptosis

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005819	spindle

Protein Structure and Domains

PDB ID

MGI:109634

InterPro

IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR013867 Telomere repeat-binding factor, dimerisation domain
IPR017357 Telomeric repeat-binding factor 1/2
IPR017877 Myb-like domain

PFAM

PF00249
PF08558

PRINTS

PIRSF

PIRSF038016

SMART

SM00717

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt