Version 5.4
Mus musculus Protein: Orc3
Summary
InnateDB Protein IDBP-134940.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Orc3
Protein Name origin recognition complex, subunit 3
Synonyms Orc3l;
Species Mus musculus
Ensembl Protein ENSMUSP00000048319
InnateDB Gene IDBG-134938 (Orc3)
Protein Structure
UniProt Annotation
Function Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0061351 neural precursor cell proliferation
Cellular Component
GO:0000808 origin recognition complex
GO:0005664 nuclear origin of replication recognition complex
Protein Structure and Domains
PDB ID MGI:1354944
InterPro IPR020795 Origin recognition complex, subunit 3
PFAM PF07034
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JK30
PhosphoSite PhosphoSite-Q9JK30
TrEMBL
UniProt Splice Variant
Entrez Gene 50793
UniGene Mm.399624
RefSeq NP_056639
MGI ID
MGI Symbol Orc3
OMIM
CCDS CCDS18028
HPRD
IMGT
EMBL AB190257 AJ132830 AK045388 AK086579 AL807397 AL928738 BC061252
GenPept AAH61252 BAC32339 BAC39695 BAD91665 CAB76399 CAM16474 CAM16475 CAM26869 CAM26870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca