InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp6nl

Summary

InnateDB Protein

IDBP-135043.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp6nl

Protein Name

USP6 N-terminal like

Synonyms

AI316785; mKIAA0019; RNTRE; TRE2NL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043178

InnateDB Gene

IDBG-135039 (Usp6nl)

Protein Structure

UniProt Annotation

Function

Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005097	Rab GTPase activator activity

Biological Process

GO:0007030	Golgi organization
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0035526	retrograde transport, plasma membrane to Golgi