Version 5.4
Mus musculus Protein: Cnot4
Summary
InnateDB Protein IDBP-135347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnot4
Protein Name CCR4-NOT transcription complex, subunit 4
Synonyms Not4; Not4h; Not4hp;
Species Mus musculus
Ensembl Protein ENSMUSP00000044137
InnateDB Gene IDBG-135345 (Cnot4)
Protein Structure
UniProt Annotation
Function Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045087 innate immune response (InnateDB)
GO:0051865 protein autoubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030014 CCR4-NOT complex
Protein Structure and Domains
PDB ID MGI:1859026
InterPro IPR000504 RNA recognition motif domain
IPR001841 Zinc finger, RING-type
IPR003954 RNA recognition motif domain, eukaryote
PFAM PF00076
PF13639
PF14634
PRINTS
PIRSF
SMART SM00360
SM00184
SM00361
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BT14
PhosphoSite PhosphoSite-Q8BT14
TrEMBL
UniProt Splice Variant
Entrez Gene 53621
UniGene Mm.414351
RefSeq NP_058573
MGI ID 2CPI
MGI Symbol Cnot4
OMIM
CCDS CCDS19999
HPRD
IMGT
EMBL AK009234 AK028190 AK032248 BC058778 U71269
GenPept AAD00181 AAH58778 BAB26155 BAC25801 BAC27779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca