Mus musculus Gene: Cnot4
Summary
InnateDB Gene IDBG-135345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnot4
Gene Name CCR4-NOT transcription complex, subunit 4
Synonyms Not4; Not4h; Not4hp
Species Mus musculus
Ensembl Gene ENSMUSG00000038784
Encoded Proteins
CCR4-NOT transcription complex, subunit 4
CCR4-NOT transcription complex, subunit 4
CCR4-NOT transcription complex, subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Cnot4 enhances JAK/STAT pathway-dependent gene expression by positively regulating IFN-gamma- and IL4-induced STAT-mediated gene responses. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] CNOT4 enhances JAK/STAT pathway-dependent gene expression by positively regulating IFN-gamma- and IL4-induced STAT-mediated gene responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080802:
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:35022066-35133737
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000044163 ENSMUSP00000044137
ENSMUST00000114993 ENSMUSP00000110645
ENSMUST00000114989 ENSMUSP00000110640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045087 innate immune response (InnateDB)
GO:0051865 protein autoubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030014 CCR4-NOT complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Deadenylation of mRNA pathway
Gene Expression pathway
Deadenylation-dependent mRNA decay pathway
KEGG
RNA degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Deadenylation of mRNA pathway
Deadenylation-dependent mRNA decay pathway
Gene Expression pathway
KEGG
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.214525 Mm.398182 Mm.412276 Mm.414351
RefSeq NM_001164411 NM_001164412 NM_001164413 NM_001164414 NM_016877 XM_006506379
OMIM
CCDS CCDS19999 CCDS51746 CCDS51747
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas