InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grk1

Summary

InnateDB Protein

IDBP-135369.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grk1

Protein Name

G protein-coupled receptor kinase 1

Synonyms

Gprk1; Rhok; Rk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033827

InnateDB Gene

IDBG-135367 (Grk1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050254	rhodopsin kinase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008594	photoreceptor cell morphogenesis
GO:0009416	response to light stimulus
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0042327	positive regulation of phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0060060	post-embryonic retina morphogenesis in camera-type eye

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1345146

InterPro

IPR000239 GPCR kinase
IPR000342 Regulator of G protein signalling domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016137 Regulator of G protein signalling superfamily
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00615
PF00069
PF07714

PRINTS

PR00717
PR01301
PR00109

PIRSF

SMART

SM00133
SM00220
SM00315
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt