InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grk1

Summary

InnateDB Gene

IDBG-135367.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grk1

Gene Name

G protein-coupled receptor kinase 1

Synonyms

Gprk1; Rhok; Rk

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031450

Encoded Proteins

IDBP-135369

G protein-coupled receptor kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185974:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:13405081-13421945

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000033827

ENSMUSP00000033827

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050254	rhodopsin kinase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008594	photoreceptor cell morphogenesis
GO:0009416	response to light stimulus
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0042327	positive regulation of phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0060060	post-embryonic retina morphogenesis in camera-type eye