InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syn1

Summary

InnateDB Protein

IDBP-135540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syn1

Protein Name

synapsin I

Synonyms

Syn-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080568

InnateDB Gene

IDBG-135538 (Syn1)

Protein Structure

UniProt Annotation

Function

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. Regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level.

Subcellular Localization

Cell junction, synapse {ECO:0000269PubMed:11571277}. Golgi apparatus {ECO:0000269PubMed:11571277}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0007269	neurotransmitter secretion
GO:0008152	metabolic process

Cellular Component

GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

MGI:98460

InterPro

IPR001359 Synapsin
IPR013651 ATP-grasp fold, RimK-type
IPR016185 Pre-ATP-grasp domain
IPR019736 Synapsin, phosphorylation site
IPR020897 Synapsin, pre-ATP-grasp domain
IPR020898 Synapsin, ATP-binding domain

PFAM

PF08443
PF10581
PF02078
PF02750

PRINTS

PR01368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88935