InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Meox2

Summary

InnateDB Protein

IDBP-135627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Meox2

Protein Name

mesenchyme homeobox 2

Synonyms

AI528662; Gax; Mox-2; Mox2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043587

InnateDB Gene

IDBG-135625 (Meox2)

Protein Structure

UniProt Annotation

Function

Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}. Nucleus speckle {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001525	angiogenesis
GO:0001757	somite specification
GO:0006355	regulation of transcription, DNA-templated
GO:0007519	skeletal muscle tissue development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060021	palate development
GO:0060173	limb development
GO:0070997	neuron death