InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Meox2

Summary

InnateDB Gene

IDBG-135625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Meox2

Gene Name

mesenchyme homeobox 2

Synonyms

AI528662; Gax; Mox-2; Mox2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036144

Encoded Proteins

IDBP-135627

mesenchyme homeobox 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106511:
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer\'s disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:37108540-37179534

Strand

Forward strand

Band

Transcripts

ENSMUST00000041183

ENSMUSP00000043587

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001525	angiogenesis
GO:0001757	somite specification
GO:0006355	regulation of transcription, DNA-templated
GO:0007519	skeletal muscle tissue development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060021	palate development
GO:0060173	limb development
GO:0070997	neuron death

Cellular Component

GO:0005737	cytoplasm
GO:0016607	nuclear speck

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000106511

View Gene Order

ENSBTAG00000003238

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.341398

RefSeq

NM_008584

OMIM

CCDS

CCDS25888

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas