Version 5.4
Mus musculus Protein: Itih2
Summary
InnateDB Protein IDBP-135662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itih2
Protein Name inter-alpha trypsin inhibitor, heavy chain 2
Synonyms AI747202; Intin2; Itih-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000046530
InnateDB Gene IDBG-135660 (Itih2)
Protein Structure
UniProt Annotation
Function May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in both liver and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID MGI:96619
InterPro IPR002035 von Willebrand factor, type A
IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
IPR013694 VIT domain
PFAM PF00092
PF06668
PF08487
PF13757
PRINTS
PIRSF
SMART SM00327
SM00609
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61703
PhosphoSite PhosphoSite-Q61703
TrEMBL G3X977
UniProt Splice Variant
Entrez Gene 16425
UniGene Mm.182043
RefSeq NP_034712
MGI ID
MGI Symbol Itih2
OMIM
CCDS CCDS15677
HPRD
IMGT
EMBL AK133782 AL772367 CH466542 X70392
GenPept BAE21837 CAA49842 CAM13914 EDL08004

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca