Version 5.4
Mus musculus Protein: Cfp
Summary
InnateDB Protein IDBP-135736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cfp
Protein Name complement factor properdin
Synonyms BCFG; Pfc;
Species Mus musculus
Ensembl Protein ENSMUSP00000001156
InnateDB Gene IDBG-135734 (Cfp)
Protein Structure
UniProt Annotation
Function A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006957 complement activation, alternative pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID MGI:97545
InterPro IPR000884 Thrombospondin, type 1 repeat
PFAM PF00090
PRINTS
PIRSF
SMART SM00209
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P11680
PhosphoSite PhosphoSite-P11680
TrEMBL A2AE15
UniProt Splice Variant
Entrez Gene 18636
UniGene Mm.408590
RefSeq NP_032849
MGI ID
MGI Symbol Cfp
OMIM
CCDS CCDS30047
HPRD
IMGT
EMBL AK150212 AK152782 AK159291 AK171374 BC132369 BC138306 CH466625 X12905
GenPept AAI32370 AAI38307 BAE29382 BAE31492 BAE34967 BAE42416 CAA31389 EDL00734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca