InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Btn1a1

Summary

InnateDB Protein

IDBP-135789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Btn1a1

Protein Name

butyrophilin, subfamily 1, member A1

Synonyms

Btn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041013

InnateDB Gene

IDBG-135787 (Btn1a1)

Protein Structure

UniProt Annotation

Function

May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. {ECO:0000250, ECO:0000269PubMed:20208008}.

Subcellular Localization

Membrane; Single-pass type I membrane protein. Note=Secreted in association with the milk-fat-globule membrane during lactation.

Disease Associations

Tissue Specificity

Strongly expressed in lactating mammary tissue (at protein level). About 100-fold lower levels in virgin mammary tissue. Also detected in spleen and thymus at 10-20 times lower levels compared to those detected in virgin mammary gland. Very low levels in several other tissues, including brain, heart, kidney, lymph node, lung and small intestine. In the thymus, detected in the stroma, in epithelial cells (at protein level). Most prominent in medullary areas of the thymus and at the corticomedullary junction (at protein level). {ECO:0000269PubMed:20208008}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005615	extracellular space
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:103118

InterPro

IPR001870 B30.2/SPRY domain
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR007110 Immunoglobulin-like domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set
IPR018355 SPla/RYanodine receptor subgroup

PFAM

PF00622
PF13765
PF07686
PF08205

PRINTS

PR01407

PIRSF

SMART

SM00406
SM00409
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt