InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itih5

Summary

InnateDB Protein

IDBP-135808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itih5

Protein Name

inter-alpha (globulin) inhibitor H5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026886

InnateDB Gene

IDBG-135806 (Itih5)

Protein Structure

UniProt Annotation

Function

May act as a tumor suppressor. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0008312	7S RNA binding

Biological Process

GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0008150	biological_process
GO:0010951	negative regulation of endopeptidase activity
GO:0030212	hyaluronan metabolic process

Cellular Component

GO:0005575	cellular_component
GO:0005576	extracellular region
GO:0048500	signal recognition particle

Protein Structure and Domains

PDB ID

MGI:1925751

InterPro

IPR002035 von Willebrand factor, type A
IPR009018 Signal recognition particle, SRP9/SRP14 subunit
IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
IPR013694 VIT domain

PFAM

PF00092
PF06668
PF08487
PF13757

PRINTS

PIRSF

SMART

SM00327
SM00609

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BJD1