Version 5.4
Mus musculus Gene: Itih5
Summary
InnateDB Gene IDBG-135806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itih5
Gene Name inter-alpha (globulin) inhibitor H5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025780
Encoded Proteins
IDBP-135808
inter-alpha (globulin) inhibitor H5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123243:
This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:10153571-10256529
Strand Forward strand
Band A1
Transcripts
ENSMUST00000026886 ENSMUSP00000026886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0008312 7S RNA binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0008150 biological_process
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0048500 signal recognition particle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123243
View Gene Order
ENSBTAG00000013004
Not yet available
Cross-References
SwissProt Q8BJD1
TrEMBL
UniProt Splice Variant
Entrez Gene 209378
UniGene Mm.313876
RefSeq NM_172471 XM_006497435
OMIM
CCDS CCDS15678
HPRD
IMGT
MGI ID MGI:1925751
MGI Symbol Itih5
EMBL AK087428 AK134707 AK140756 AL772367 AL953853 BC043314 BC062196
GenPept AAH43314 AAH62196 BAC39871 BAE22250 BAE24467 CAM13913 CAM26660
RNA Seq Atlas 209378

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca