InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mtpn

Summary

InnateDB Protein

IDBP-135886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtpn

Protein Name

myotrophin

Synonyms

5033418D15Rik; Gcdp; V1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031866

InnateDB Gene

IDBG-135884 (Mtpn)

Protein Structure

UniProt Annotation

Function

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. {ECO:0000250, ECO:0000269PubMed:20538588}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006584	catecholamine metabolic process
GO:0010557	positive regulation of macromolecule biosynthetic process
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0016049	cell growth
GO:0021707	cerebellar granule cell differentiation
GO:0030307	positive regulation of cell growth
GO:0043403	skeletal muscle tissue regeneration
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051146	striated muscle cell differentiation
GO:0051247	positive regulation of protein metabolic process
GO:2000812	regulation of barbed-end actin filament capping

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008290	F-actin capping protein complex
GO:0030424	axon
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome