InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mtpn

Summary

InnateDB Gene

IDBG-135884.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtpn

Gene Name

myotrophin

Synonyms

5033418D15Rik; Gcdp; V1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029840

Encoded Proteins

IDBP-135886

myotrophin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105887:
A bi-cistronic transcript encodes the products of both the myotrophin and leucine zipper protein 6 genes, which are located on chromosome 7. A cryptic ORF at the 3' end of the myotrophin transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008] The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:35508906-35539888

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031866

ENSMUSP00000031866

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006584	catecholamine metabolic process
GO:0010557	positive regulation of macromolecule biosynthetic process
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0016049	cell growth
GO:0021707	cerebellar granule cell differentiation
GO:0030307	positive regulation of cell growth
GO:0043403	skeletal muscle tissue regeneration
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051146	striated muscle cell differentiation
GO:0051247	positive regulation of protein metabolic process
GO:2000812	regulation of barbed-end actin filament capping

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008290	F-actin capping protein complex
GO:0030424	axon
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105887

View Gene Order

ENSBTAG00000007806

Not yet available

Cross-References

SwissProt

P62774

TrEMBL

UniProt Splice Variant

Entrez Gene

14489

UniGene

Mm.182746 Mm.402298 Mm.472387

RefSeq

NM_008098

OMIM

CCDS

CCDS20002

HPRD

IMGT

MGI ID

MGI:99445

MGI Symbol

Mtpn

EMBL

AK002620 AK028027 AK049398 AK083888 AK132029 AK145755 AK146305 AK146473 AK150750 AK151106 AK151147 AK151485 AK151564 AK151640 AK151687 AK152272 BC043084 BC054811 U20290

GenPept

AAA86719 AAH43084 AAH54811 BAB22235 BAC25707 BAC33734 BAC39050 BAE20953 BAE26630 BAE27061 BAE27198 BAE29820 BAE30116 BAE30153 BAE30438 BAE30506 BAE30570 BAE30611 BAE31088

RNA Seq Atlas

14489