InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agtr2

Summary

InnateDB Protein

IDBP-136034.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agtr2

Protein Name

angiotensin II receptor, type 2

Synonyms

AI316812; AW107640;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086592

InnateDB Gene

IDBG-136032 (Agtr2)

Protein Structure

UniProt Annotation

Function

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. {ECO:0000269PubMed:15539617}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15539617}; Multi-pass membrane protein {ECO:0000269PubMed:15539617}.

Disease Associations

Tissue Specificity

Expressed at highest levels in adrenal gland and uterus. {ECO:0000269PubMed:15539617}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017046	peptide hormone binding

Biological Process

GO:0001822	kidney development
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0002033	vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
GO:0002035	brain renin-angiotensin system
GO:0006883	cellular sodium ion homeostasis
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0008284	positive regulation of cell proliferation
GO:0010243	response to organonitrogen compound
GO:0010459	negative regulation of heart rate
GO:0010700	negative regulation of norepinephrine secretion
GO:0021695	cerebellar cortex development
GO:0032304	negative regulation of icosanoid secretion
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0035556	intracellular signal transduction
GO:0035566	regulation of metanephros size
GO:0035640	exploration behavior
GO:0035815	positive regulation of renal sodium excretion
GO:0035932	aldosterone secretion
GO:0038166	angiotensin-activated signaling pathway
GO:0042416	dopamine biosynthetic process
GO:0042990	regulation of transcription factor import into nucleus
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045909	positive regulation of vasodilation
GO:0048147	negative regulation of fibroblast proliferation
GO:0050715	positive regulation of cytokine secretion
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060993	kidney morphogenesis
GO:0061049	cell growth involved in cardiac muscle cell development
GO:0071549	cellular response to dexamethasone stimulus
GO:0072300	positive regulation of metanephric glomerulus development
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:87966

InterPro

IPR000147 Angiotensin II receptor type 2
IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR000496 Bradykinin receptor family
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00636
PR00241
PR00237
PR00657
PR00425

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35374