Version 5.4
Mus musculus Protein: Dgki
Summary
InnateDB Protein IDBP-136086.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Dgki
Protein Name diacylglycerol kinase, iota
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000047858
InnateDB Gene IDBG-136082 (Dgki)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017016 Ras GTPase binding
Biological Process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016310 phosphorylation
GO:0032317 regulation of Rap GTPase activity
GO:0035556 intracellular signal transduction
GO:0043086 negative regulation of catalytic activity
GO:0046579 positive regulation of Ras protein signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2443430
InterPro IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002110 Ankyrin repeat
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR020683 Ankyrin repeat-containing domain
PFAM PF00609
PF00781
PF00023
PF13606
PF00130
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00045
SM00046
SM00248
SM00109
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-ENSMUSP00000047858
TrEMBL D3Z519
UniProt Splice Variant
Entrez Gene 320127
UniGene Mm.442505
RefSeq
MGI ID
MGI Symbol Dgki
OMIM
CCDS
HPRD
IMGT
EMBL AC114574 AC154019 AC159480 AC184160 AC185507
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca