InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dgki

Summary

InnateDB Gene

IDBG-136082.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgki

Gene Name

diacylglycerol kinase, iota

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038665

Encoded Proteins

IDBP-136084

diacylglycerol kinase, iota

IDBP-136086

diacylglycerol kinase, iota

IDBP-136088

diacylglycerol kinase, iota

IDBP-788888

diacylglycerol kinase, iota

IDBP-788889

diacylglycerol kinase, iota

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157680:
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:36846022-37300184

Strand

Reverse strand

Band

Transcripts

ENSMUST00000090314	ENSMUSP00000087788
ENSMUST00000042075	ENSMUSP00000047858
ENSMUST00000101532	ENSMUSP00000099071
ENSMUST00000150300	ENSMUSP00000138457
ENSMUST00000138286	ENSMUSP00000138628
ENSMUST00000143046
ENSMUST00000146656
ENSMUST00000136457

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005095	GTPase inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017016	Ras GTPase binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016310	phosphorylation
GO:0032317	regulation of Rap GTPase activity
GO:0035556	intracellular signal transduction
GO:0043086	negative regulation of catalytic activity
GO:0046579	positive regulation of Ras protein signal transduction