InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Topors

Summary

InnateDB Protein

IDBP-136141.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Topors

Protein Name

topoisomerase I binding, arginine/serine-rich

Synonyms

AW105885; LUN; p53BP3/LUN; TP53BPL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046843

InnateDB Gene

IDBG-136139 (Topors)

Protein Structure

UniProt Annotation

Function

Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage- induced cell death through IKBKE sumoylation. {ECO:0000269PubMed:15703819, ECO:0000269PubMed:15735665}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15703819, ECO:0000269PubMed:15735665}. Nucleus, PML body {ECO:0000250}. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003823	antigen binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0044547	DNA topoisomerase binding
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006513	protein monoubiquitination
GO:0006974	cellular response to DNA damage stimulus
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016925	protein sumoylation
GO:0034504	protein localization to nucleus
GO:0042127	regulation of cell proliferation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0051457	maintenance of protein location in nucleus
GO:0070936	protein K48-linked ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000922	spindle pole
GO:0000930	gamma-tubulin complex
GO:0005634	nucleus
GO:0005814	centriole
GO:0016605	PML body
GO:0016607	nuclear speck
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body