InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD9

Summary

InnateDB Protein

IDBP-13616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD9

Protein Name

CD9 molecule

Synonyms

BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29; TSPAN29;

Species

Homo sapiens

Ensembl Protein

ENSP00000371958

InnateDB Gene

IDBG-13612 (CD9)

Protein Structure

UniProt Annotation

Function

Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion. {ECO:0000269PubMed:14575715, ECO:0000269PubMed:7511626, ECO:0000269PubMed:8478605}.

Subcellular Localization

Membrane {ECO:0000269PubMed:19640571}; Multi-pass membrane protein {ECO:0000269PubMed:19640571}. Cell membrane {ECO:0000269PubMed:19640571}; Multi-pass membrane protein {ECO:0000269PubMed:19640571}.

Disease Associations

Tissue Specificity

Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells. {ECO:0000269PubMed:19640571}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	37 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0002576	platelet degranulation
GO:0006928	cellular component movement
GO:0007155	cell adhesion
GO:0007338	single fertilization
GO:0007342	fusion of sperm to egg plasma membrane
GO:0007420	brain development
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0009414	response to water deprivation
GO:0014003	oligodendrocyte development
GO:0030168	platelet activation
GO:0030913	paranodal junction assembly
GO:0032504	multicellular organism reproduction

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031092	platelet alpha granule membrane
GO:0070062	extracellular vesicular exosome