InnateDB Protein
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IDBP-136188.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Scin
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Protein Name
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scinderin
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Synonyms
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adseverin; AW545522;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000077573
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InnateDB Gene
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IDBG-136186 (Scin)
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Protein Structure
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Function |
Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity). Isoform 2 fails to nucleate actin polymerization, although it severs and caps actin filaments in a Ca(2+)-dependent manner. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1306794
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InterPro |
IPR007122
Villin/Gelsolin
IPR007123
Gelsolin-like domain
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PFAM |
PF00626
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PRINTS |
PR00597
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PIRSF |
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SMART |
SM00262
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TIGRFAMs |
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Modification |
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SwissProt |
Q60604
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PhosphoSite |
PhosphoSite-Q60604
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
20259
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UniGene |
Mm.2416
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RefSeq |
NP_033158
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MGI ID |
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MGI Symbol |
Scin
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OMIM |
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CCDS |
CCDS25891
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HPRD |
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IMGT |
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EMBL |
AK133484
BC063328
U04354
Y13971
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GenPept |
AAB61682
AAH63328
BAE21681
CAA74304
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