Version 5.4
Mus musculus Gene: Scin
Summary
InnateDB Gene IDBG-136186.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scin
Gene Name scinderin
Synonyms adseverin; AW545522
Species Mus musculus
Ensembl Gene ENSMUSG00000002565
Encoded Proteins
IDBP-136188
scinderin
IDBP-136190
scinderin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006747:
SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:40059769-40134228
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000078481 ENSMUSP00000077573
ENSMUST00000002640 ENSMUSP00000002640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0032330 regulation of chondrocyte differentiation
GO:0043065 positive regulation of apoptotic process
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0051014 actin filament severing
GO:0051693 actin filament capping
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000006747
View Gene Order
ENSBTAG00000009786
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q60604
TrEMBL Q69Z71
UniProt Splice Variant
Entrez Gene 20259
UniGene Mm.2416
RefSeq NM_001146196 NM_009132
OMIM
CCDS CCDS25891 CCDS49055
HPRD
IMGT
MGI ID MGI:1306794
MGI Symbol Scin
EMBL AK133484 AK173295 BC063328 U04354 Y13971
GenPept AAB61682 AAH63328 BAD32573 BAE21681 CAA74304
RNA Seq Atlas 20259

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca