InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scin

Summary

InnateDB Protein

IDBP-136190.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scin

Protein Name

scinderin

Synonyms

adseverin; AW545522;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002640

InnateDB Gene

IDBG-136186 (Scin)

Protein Structure

UniProt Annotation

Function

Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity). Isoform 2 fails to nucleate actin polymerization, although it severs and caps actin filaments in a Ca(2+)-dependent manner. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding

Biological Process

GO:0008285	negative regulation of cell proliferation
GO:0032330	regulation of chondrocyte differentiation
GO:0043065	positive regulation of apoptotic process
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0051014	actin filament severing
GO:0051693	actin filament capping