InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akr1d1

Summary

InnateDB Protein

IDBP-136335.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akr1d1

Protein Name

aldo-keto reductase family 1, member D1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048830

InnateDB Gene

IDBG-136333 (Akr1d1)

Protein Structure

UniProt Annotation

Function

Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0047787	delta4-3-oxosteroid 5beta-reductase activity

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0007586	digestion
GO:0008207	C21-steroid hormone metabolic process
GO:0008209	androgen metabolic process
GO:0030573	bile acid catabolic process
GO:0055114	oxidation-reduction process