InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnaja1

Summary

InnateDB Protein

IDBP-136350.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnaja1

Protein Name

DnaJ (Hsp40) homolog, subfamily A, member 1

Synonyms

Hsj2; Nedd7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030118

InnateDB Gene

IDBG-136348 (Dnaja1)

Protein Structure

UniProt Annotation

Function

Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. {ECO:0000250, ECO:0000269PubMed:14752510}.

Subcellular Localization

Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasm {ECO:0000250}. Microsome {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0030544	Hsp70 protein binding
GO:0031072	heat shock protein binding
GO:0046872	metal ion binding
GO:0050750	low-density lipoprotein particle receptor binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0007283	spermatogenesis
GO:0009408	response to heat
GO:0030317	sperm motility
GO:0030521	androgen receptor signaling pathway
GO:0042769	DNA damage response, detection of DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043508	negative regulation of JUN kinase activity
GO:0051223	regulation of protein transport
GO:0070585	protein localization to mitochondrion

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1270129

InterPro

IPR001305 Heat shock protein DnaJ, cysteine-rich domain
IPR001623 DnaJ domain
IPR002939 Chaperone DnaJ, C-terminal
IPR008971 HSP40/DnaJ peptide-binding

PFAM

PF00684
PF00226
PF01556

PRINTS

PR00625

PIRSF

SMART

SM00271

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt