InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dock4

Summary

InnateDB Protein

IDBP-136541.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dock4

Protein Name

dedicator of cytokinesis 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047387

InnateDB Gene

IDBG-136539 (Dock4)

Protein Structure

UniProt Annotation

Function

Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP (By similarity). {ECO:0000250}.

Subcellular Localization

Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Note=Defects in Dock4 are involved in the cause of some cancers, which are probably due to lack of Rap1 activation. {ECO:0000269PubMed:12628187}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0030165	PDZ domain binding
GO:0030675	Rac GTPase activator activity
GO:0030971	receptor tyrosine kinase binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032855	positive regulation of Rac GTPase activity
GO:0060326	cell chemotaxis

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0032420	stereocilium
GO:0032421	stereocilium bundle

Protein Structure and Domains

PDB ID

MGI:1918006

InterPro

IPR000008 C2 domain
IPR001452 SH3 domain
IPR008936 Rho GTPase activation protein
IPR010703 Dedicator of cytokinesis C-terminal
IPR011511 Variant SH3 domain

PFAM

PF00168
PF00018
PF14604
PF06920
PF07653

PRINTS

PR00360
PR00452

PIRSF

SMART

SM00239
SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt