Version 5.4
Mus musculus Gene: Dock4
Summary
InnateDB Gene IDBG-136539.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dock4
Gene Name dedicator of cytokinesis 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000035954
Encoded Proteins
IDBP-136541
dedicator of cytokinesis 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128512:
This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:40446053-40846486
Strand Forward strand
Band B1
Transcripts
ENSMUST00000037488 ENSMUSP00000047387
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0030165 PDZ domain binding
GO:0030675 Rac GTPase activator activity
GO:0030971 receptor tyrosine kinase binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032855 positive regulation of Rac GTPase activity
GO:0060326 cell chemotaxis
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0032420 stereocilium
GO:0032421 stereocilium bundle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000128512
View Gene Order
ENSBTAG00000021182
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt P59764
TrEMBL
UniProt Splice Variant
Entrez Gene 238130
UniGene Mm.341423
RefSeq NM_172803 XM_006515085
OMIM
CCDS CCDS25895
HPRD
IMGT
MGI ID MGI:1918006
MGI Symbol Dock4
EMBL AK122353
GenPept BAC65635
RNA Seq Atlas 238130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca