InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il2ra

Summary

InnateDB Protein

IDBP-136656.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il2ra

Protein Name

interleukin 2 receptor, alpha chain

Synonyms

CD25; Il2r; Ly-43;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028111

InnateDB Gene

IDBG-136654 (Il2ra)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-2.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	2 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004911	interleukin-2 receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0019976	interleukin-2 binding

Biological Process

GO:0002437	inflammatory response to antigenic stimulus
GO:0006924	activation-induced cell death of T cells
GO:0007219	Notch signaling pathway
GO:0038110	interleukin-2-mediated signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0043029	T cell homeostasis
GO:0045582	positive regulation of T cell differentiation
GO:0046013	regulation of T cell homeostatic proliferation
GO:0050672	negative regulation of lymphocyte proliferation
GO:0050687	negative regulation of defense response to virus
GO:0050728	negative regulation of inflammatory response
GO:0050777	negative regulation of immune response