Version 5.4
Mus musculus Gene: Il2ra
Summary
InnateDB Gene IDBG-136654.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il2ra
Gene Name interleukin 2 receptor, alpha chain
Synonyms CD25; Il2r; Ly-43
Species Mus musculus
Ensembl Gene ENSMUSG00000026770
Encoded Proteins
IDBP-136656
interleukin 2 receptor, alpha chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134460:
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:11642792-11693191
Strand Forward strand
Band A1
Transcripts
ENSMUST00000028111 ENSMUSP00000028111
ENSMUST00000150890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 2 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004911 interleukin-2 receptor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0019976 interleukin-2 binding
Biological Process
GO:0002437 inflammatory response to antigenic stimulus
GO:0006924 activation-induced cell death of T cells
GO:0007219 Notch signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0043029 T cell homeostasis
GO:0045582 positive regulation of T cell differentiation
GO:0046013 regulation of T cell homeostatic proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050687 negative regulation of defense response to virus
GO:0050728 negative regulation of inflammatory response
GO:0050777 negative regulation of immune response
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134460
View Gene Order
ENSBTAG00000020892
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261365
Interleukin-2 signaling pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_210793
Interleukin receptor SHC signaling pathway
REACT_261687
Signaling by Interleukins pathway
REACT_207835
G-protein beta:gamma signalling pathway
REACT_225836
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_188257
Signal Transduction pathway
REACT_223974
G beta:gamma signalling through PI3Kgamma pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04144
Endocytosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-2 signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_14
IL2 pathway
REACTOME
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_604
Hemostasis pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04144
Endocytosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-2 signaling pathway
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
il2_1pathway
IL2-mediated signaling events
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
il12_stat4pathway
IL12 signaling mediated by STAT4
shp2_pathway
SHP2 signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
il2_pi3kpathway
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.915
RefSeq NM_008367
OMIM
CCDS CCDS15685
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca