InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sema3c

Summary

InnateDB Protein

IDBP-136683.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema3c

Protein Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Synonyms

1110036B02Rik; Semae; SemE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030568

InnateDB Gene

IDBG-136681 (Sema3c)

Protein Structure

UniProt Annotation

Function

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance. {ECO:0000269PubMed:11688556, ECO:0000269PubMed:15239958, ECO:0000269PubMed:17021275}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding

Biological Process

GO:0001755	neural crest cell migration
GO:0001756	somitogenesis
GO:0001974	blood vessel remodeling
GO:0003151	outflow tract morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0003350	pulmonary myocardium development
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0007507	heart development
GO:0009791	post-embryonic development
GO:0021915	neural tube development
GO:0060174	limb bud formation
GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching

Cellular Component

GO:0005615	extracellular space
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:107557

InterPro

IPR001627 Sema domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF07679

PRINTS

PIRSF

SMART

SM00630
SM00408
SM00409
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q62181