InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cthrc1

Summary

InnateDB Protein

IDBP-136727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cthrc1

Protein Name

collagen triple helix repeat containing 1

Synonyms

1110014B07Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070018

InnateDB Gene

IDBG-136725 (Cthrc1)

Protein Structure

UniProt Annotation

Function

May act as a negative regulator of collagen matrix deposition. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0017147	Wnt-protein binding

Biological Process

GO:0016477	cell migration
GO:0032092	positive regulation of protein binding
GO:0033690	positive regulation of osteoblast proliferation
GO:0043932	ossification involved in bone remodeling
GO:0045669	positive regulation of osteoblast differentiation
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060122	inner ear receptor stereocilium organization
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090103	cochlea morphogenesis
GO:0090177	establishment of planar polarity involved in neural tube closure

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1915838

InterPro

IPR008160 Collagen triple helix repeat

PFAM

PF01391

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D1D6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

68588

UniGene

RefSeq

NP_081054

MGI ID

MGI Symbol

Cthrc1

OMIM

CCDS

CCDS27442

HPRD

IMGT

EMBL

AC164883 AK003674 AK151282 CH466541

GenPept

BAB22930 BAE30268 EDL08785