InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfx1

Summary

InnateDB Protein

IDBP-136747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfx1

Protein Name

nuclear transcription factor, X-box binding 1

Synonyms

1300017N15Rik; 3000003M19Rik; NFX.1; TEG-42; Tex42;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089203

InnateDB Gene

IDBG-136741 (Nfx1)

Protein Structure

UniProt Annotation

Function

Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269PubMed:12047746}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in thymus. {ECO:0000269PubMed:12047746}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045347	negative regulation of MHC class II biosynthetic process