InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nfx1

Summary

InnateDB Gene

IDBG-136741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfx1

Gene Name

nuclear transcription factor, X-box binding 1

Synonyms

1300017N15Rik; 3000003M19Rik; NFX.1; TEG-42; Tex42

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028423

Encoded Proteins

IDBP-136743

nuclear transcription factor, X-box binding 1

IDBP-136745

nuclear transcription factor, X-box binding 1

IDBP-136747

nuclear transcription factor, X-box binding 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000086102:
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:40970906-41025993

Strand

Forward strand

Band

Transcripts

ENSMUST00000030133	ENSMUSP00000030133
ENSMUST00000098143	ENSMUSP00000095747
ENSMUST00000091614	ENSMUSP00000089203
ENSMUST00000143798
ENSMUST00000124595
ENSMUST00000136717
ENSMUST00000131305

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045347	negative regulation of MHC class II biosynthetic process

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000086102

View Gene Order

ENSBTAG00000012385

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

INOH website

Tryptophan degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.247456 Mm.399601 Mm.402765 Mm.407348 Mm.427435 Mm.427888 Mm.428377 Mm.429314 Mm.447670

RefSeq

NM_001290448 NM_001290449 NM_023739 XM_006538318 XM_006538320

OMIM

CCDS

CCDS18054 CCDS71359 CCDS71360

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas