InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc22a3

Summary

InnateDB Protein

IDBP-136762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc22a3

Protein Name

solute carrier family 22 (organic cation transporter), member 3

Synonyms

EMT; Oct3; Orct3; Slca22a3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024595

InnateDB Gene

IDBG-136760 (Slc22a3)

Protein Structure

UniProt Annotation

Function

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269PubMed:10966924, ECO:0000305}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in placenta and in kidney cortex, but not in medulla. Low levels found in brain. In the kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule, but not in the glomerulus. {ECO:0000269PubMed:10966924, ECO:0000269PubMed:9933568, ECO:0000305}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005329	dopamine transmembrane transporter activity
GO:0005515	protein binding
GO:0015075	ion transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0019534	toxin transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0015695	organic cation transport
GO:0015697	quaternary ammonium group transport
GO:0015844	monoamine transport
GO:0015872	dopamine transport
GO:0032098	regulation of appetite
GO:0034220	ion transmembrane transport
GO:0051608	histamine transport
GO:0051615	histamine uptake
GO:0055085	transmembrane transport
GO:1901998	toxin transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1333817

InterPro

IPR004749 Organic cation transport protein
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WTW5

PhosphoSite