InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnm1l

Summary

InnateDB Protein

IDBP-136830.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Dnm1l

Protein Name

dynamin 1-like

Synonyms

6330417M19Rik; AI450666; Dlp1; Dnmlp1; Drp1; python;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093945

InnateDB Gene

IDBG-136828 (Dnm1l)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000266	mitochondrial fission
GO:0001836	release of cytochrome c from mitochondria
GO:0003374	dynamin polymerization involved in mitochondrial fission
GO:0006184	GTP catabolic process
GO:0016559	peroxisome fission
GO:0032459	regulation of protein oligomerization
GO:0043065	positive regulation of apoptotic process
GO:0043653	mitochondrial fragmentation involved in apoptotic process
GO:0050714	positive regulation of protein secretion
GO:0051289	protein homotetramerization
GO:0061025	membrane fusion
GO:0070266	necroptotic process
GO:0070584	mitochondrion morphogenesis
GO:0070585	protein localization to mitochondrion
GO:0090149	membrane fission involved in mitochondrial fission
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:1900063	regulation of peroxisome organization
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1921256

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt