Version 5.4
Mus musculus Gene: Dnm1l
Summary
InnateDB Gene IDBG-136828.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnm1l
Gene Name dynamin 1-like
Synonyms 6330417M19Rik; AI450666; Dlp1; Dnmlp1; Drp1; python
Species Mus musculus
Ensembl Gene ENSMUSG00000022789
Encoded Proteins
IDBP-136830
dynamin 1-like
IDBP-136832
dynamin 1-like
IDBP-248950
dynamin 1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24733894
[Homo sapiens] Hepatitis C infection stimulates the expression of DNM1L and MFF and promotes DNM1L recruitment to mitochondria by stimulating the phosphorylation of DNM1L, leading to mitochondrial fission.
Entrez Gene
Summary This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:16312235-16359030
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000096229 ENSMUSP00000093945
ENSMUST00000023477 ENSMUSP00000023477
ENSMUST00000115749 ENSMUSP00000111415
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008289 lipid binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000266 mitochondrial fission
GO:0001836 release of cytochrome c from mitochondria
GO:0003374 dynamin polymerization involved in mitochondrial fission
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0010821 regulation of mitochondrion organization
GO:0016559 peroxisome fission
GO:0032459 regulation of protein oligomerization
GO:0043065 positive regulation of apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0050714 positive regulation of protein secretion
GO:0051289 protein homotetramerization
GO:0061025 membrane fusion
GO:0070266 necroptotic process
GO:0070584 mitochondrion morphogenesis
GO:0070585 protein localization to mitochondrion
GO:0090149 membrane fission involved in mitochondrial fission
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:1900063 regulation of peroxisome organization
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005905 coated pit
GO:0016020 membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000087470
View Gene Order
ENSBTAG00000011395
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
REACT_227007
Apoptotic execution phase pathway
REACT_219454
Apoptosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8K1M6
TrEMBL
UniProt Splice Variant
Entrez Gene 74006
UniGene Mm.218820 Mm.397868 Mm.457639
RefSeq NM_001025947 NM_001276340 NM_001276341 NM_152816 XM_006522636 XM_006522637
OMIM
CCDS CCDS27984 CCDS27985 CCDS70689
HPRD
IMGT
MGI ID MGI:1921256
MGI Symbol Dnm1l
EMBL AB079133 AK051443 AK080871 BC027538 BC040777 BC079635 CF914619
GenPept AAH27538 AAH40777 AAH79635 BAC06576 BAC34640 BAC38054
RNA Seq Atlas 74006

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca