InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnm1l

Summary

InnateDB Protein

IDBP-136832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnm1l

Protein Name

dynamin 1-like

Synonyms

6330417M19Rik; AI450666; Dlp1; Dnmlp1; Drp1; python;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023477

InnateDB Gene

IDBG-136828 (Dnm1l)

Protein Structure

UniProt Annotation

Function

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. {ECO:0000269PubMed:19578372, ECO:0000269PubMed:19752021, ECO:0000269PubMed:22564413, ECO:0000269PubMed:23283981, ECO:0000269PubMed:24508339}.

Subcellular Localization

Cytoplasm, cytosol. Golgi apparatus {ECO:0000250}. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Note=Mainly cytosolic. Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Colocalized with MARCH5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex (By similarity). Recruited to the mitochondrial outer membrane by interaction with MIEF1. Binds to phospholipid membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the cerebellum and in several regions of the cerebrum and diencephalon. Strongly expressed in the cerebellar Purkinje cells and in the pontile giant neurons. {ECO:0000269PubMed:9422767}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008289	lipid binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000266	mitochondrial fission
GO:0003374	dynamin polymerization involved in mitochondrial fission
GO:0006184	GTP catabolic process
GO:0006897	endocytosis
GO:0016559	peroxisome fission
GO:0070266	necroptotic process
GO:0070585	protein localization to mitochondrion

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005905	coated pit
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane

Protein Structure and Domains

PDB ID

MGI:1921256

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt