Mus musculus Protein: Slc22a2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-136837.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Slc22a2 | ||||||||||||||
Protein Name | solute carrier family 22 (organic cation transporter), member 2 | ||||||||||||||
Synonyms | Oct2; Orct2; | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000041186 | ||||||||||||||
InnateDB Gene | IDBG-136835 (Slc22a2) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity (By similarity). {ECO:0000250}. | ||||||||||||||
Subcellular Localization | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Expressed in kidney and ureter. To a lower extent, also expressed in brain and embryo. {ECO:0000269PubMed:10051314}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:1335072 | ||||||||||||||
InterPro |
IPR004749
Organic cation transport protein IPR005828 General substrate transporter IPR011701 Major facilitator superfamily IPR016196 Major facilitator superfamily domain, general substrate transporter IPR020846 Major facilitator superfamily domain |
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PFAM |
PF00083
PF07690 |
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PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART | |||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | O70577 | ||||||||||||||
PhosphoSite | PhosphoSite-O70577 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 20518 | ||||||||||||||
UniGene | Mm.17322 | ||||||||||||||
RefSeq | NP_038695 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Slc22a2 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS28392 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AF481054 AJ006036 AK052658 BC015250 BC069911 | ||||||||||||||
GenPept | AAH15250 AAH69911 AAM22158 BAC35086 CAA06827 | ||||||||||||||