InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxo18

Summary

InnateDB Protein

IDBP-136866.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo18

Protein Name

F-box protein 18

Synonyms

AU015756; Fbh1; Fbx18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071495

InnateDB Gene

IDBG-136862 (Fbxo18)

Protein Structure

UniProt Annotation

Function

DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction.Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0001934	positive regulation of protein phosphorylation
GO:0008150	biological_process
GO:0032508	DNA duplex unwinding
GO:0072429	response to intra-S DNA damage checkpoint signaling
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage