InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myb

Summary

InnateDB Protein

IDBP-136899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myb

Protein Name

myeloblastosis oncogene

Synonyms

AI550390; c-myb; M16449;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020158

InnateDB Gene

IDBG-136895 (Myb)

Protein Structure

UniProt Annotation

Function

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	15 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006816	calcium ion transport
GO:0010468	regulation of gene expression
GO:0030183	B cell differentiation
GO:0045624	positive regulation of T-helper cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048538	thymus development
GO:0048566	embryonic digestive tract development
GO:0048872	homeostasis of number of cells
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0051574	positive regulation of histone H3-K9 methylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

MGI:97249

InterPro

IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR012642 Transcription regulator Wos2-domain
IPR015395 C-myb, C-terminal
IPR017877 Myb-like domain

PFAM

PF00249
PF07988
PF09316

PRINTS

PIRSF

SMART

SM00717

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P06876