InnateDB Protein
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IDBP-137015.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zc3hav1
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Protein Name
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zinc finger CCCH type, antiviral 1
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Synonyms
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1200014N16Rik; 2900058M19Rik; 9130009D18Rik; 9830115L13Rik; ARTD13; D6Bwg1452e; ZAP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000031850
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InnateDB Gene
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IDBG-137011 (Zc3hav1)
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Protein Structure
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Function |
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269PubMed:21102435}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
22 [view]
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Molecular Function |
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Biological Process |
GO:0008152
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metabolic process
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GO:0009615
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response to virus
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GO:0032481
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positive regulation of type I interferon production
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GO:0032727
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positive regulation of interferon-alpha production
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GO:0032728
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positive regulation of interferon-beta production
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GO:0032781
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positive regulation of ATPase activity
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0045071
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negative regulation of viral genome replication
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GO:0045087
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innate immune response (InnateDB)
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GO:0051607
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defense response to virus
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GO:0061014
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positive regulation of mRNA catabolic process
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GO:0071360
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cellular response to exogenous dsRNA
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GO:1900246
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positive regulation of RIG-I signaling pathway
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Cellular Component |
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PDB ID |
MGI:1926031
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InterPro |
IPR004170
WWE domain
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PFAM |
PF02825
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3UPF5
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PhosphoSite |
PhosphoSite-Q3UPF5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
78781
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UniGene |
Mm.487761
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RefSeq |
NP_083140
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MGI ID |
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MGI Symbol |
Zc3hav1
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OMIM |
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CCDS |
CCDS20012
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HPRD |
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IMGT |
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EMBL |
AK004770
AK020263
AK080334
AK143568
AK169402
AK172379
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GenPept |
BAB23549
BAB32047
BAC37881
BAE25440
BAE41148
BAE42974
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