InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zc3hav1

Summary

InnateDB Gene

IDBG-137011.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zc3hav1

Gene Name

zinc finger CCCH type, antiviral 1

Synonyms

1200014N16Rik; 2900058M19Rik; 9130009D18Rik; 9830115L13Rik; ARTD13; D6Bwg1452e; ZAP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029826

Encoded Proteins

IDBP-137015

zinc finger CCCH type, antiviral 1

IDBP-250801

zinc finger CCCH type, antiviral 1

IDBP-250803

zinc finger CCCH type, antiviral 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21102435

Zc3hav1 isoform ZAPS is selectively induced by 5'-triphosphate-modified RNA and functions as a potent stimulator of interferon responses via the RIG-I signalling pathway.

InnateDB Annotation from Orthologs

Summary

PMID 21102435

[Homo sapiens] ZC3HAV1 isoform ZAPS is selectively induced by 5'-triphosphate-modified RNA and functions as a potent stimulator of interferon responses via the RIG-I signalling pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105939:
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:38305286-38354603

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031850	ENSMUSP00000031850
ENSMUST00000114900	ENSMUSP00000110550
ENSMUST00000114898	ENSMUSP00000110548
ENSMUST00000143702

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0017151	DEAD/H-box RNA helicase binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0008152	metabolic process
GO:0009615	response to virus
GO:0032481	positive regulation of type I interferon production
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0032781	positive regulation of ATPase activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0061014	positive regulation of mRNA catabolic process
GO:0071360	cellular response to exogenous dsRNA
GO:1900246	positive regulation of RIG-I signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105939

View Gene Order

ENSBTAG00000021617

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

G3X9X5

UniProt Splice Variant

Entrez Gene

78781

UniGene

Mm.25243 Mm.398895 Mm.486484 Mm.487761

RefSeq

NM_028421 NM_028864 XM_006506779 XM_006506781

OMIM

CCDS

CCDS20012

HPRD

IMGT

MGI ID

MGI:1926031

MGI Symbol

Zc3hav1

EMBL

AC125530 CH466533

GenPept

EDL13640

RNA Seq Atlas

78781