InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adk

Summary

InnateDB Protein

IDBP-137104.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adk

Protein Name

adenosine kinase

Synonyms

2310026J05Rik; 5033405D03Rik; AI255373; AI987814; Ak;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047665

InnateDB Gene

IDBG-137102 (Adk)

Protein Structure

UniProt Annotation

Function

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

Subcellular Localization

Isoform Long: Nucleus {ECO:0000250}.Isoform Short: Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest expression in liver, testis, kidney and spleen. Lower expression in brain. Isoform Long is predominant in testis and kidney and isoform Short is predominant in the spleen. {ECO:0000269PubMed:15317590}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004001	adenosine kinase activity
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006166	purine ribonucleoside salvage
GO:0006175	dATP biosynthetic process
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0016310	phosphorylation
GO:0032922	circadian regulation of gene expression
GO:0042102	positive regulation of T cell proliferation
GO:0044209	AMP salvage
GO:0044342	type B pancreatic cell proliferation
GO:0046085	adenosine metabolic process