InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pnpla8

Summary

InnateDB Protein

IDBP-137141.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pnpla8

Protein Name

patatin-like phospholipase domain containing 8

Synonyms

1200006O19Rik; AI467579; Ipla2(gamma);

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043286

InnateDB Gene

IDBG-137137 (Pnpla8)

Protein Structure

UniProt Annotation

Function

Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0005179	hormone activity
GO:0005488	binding
GO:0047499	calcium-independent phospholipase A2 activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0008152	metabolic process
GO:0008219	cell death
GO:0019369	arachidonic acid metabolic process
GO:0034638	phosphatidylcholine catabolic process
GO:0043651	linoleic acid metabolic process
GO:0046338	phosphatidylethanolamine catabolic process
GO:0050482	arachidonic acid secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005622	intracellular
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1914702

InterPro

IPR002641 Patatin/Phospholipase A2-related
IPR016024 Armadillo-type fold
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR016179 Insulin-like

PFAM

PF01734
PF00049

PRINTS

PIRSF

SMART

SM00078

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K1N1