InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pnpla8

Summary

InnateDB Gene

IDBG-137137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pnpla8

Gene Name

patatin-like phospholipase domain containing 8

Synonyms

1200006O19Rik; AI467579; Ipla2(gamma)

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036257

Encoded Proteins

IDBP-137141

patatin-like phospholipase domain containing 8

IDBP-537024

patatin-like phospholipase domain containing 8

IDBP-538216

patatin-like phospholipase domain containing 8

IDBP-534305

patatin-like phospholipase domain containing 8

IDBP-532106

patatin-like phospholipase domain containing 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135241:
This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:44221370-44312343

Strand

Forward strand

Band

Transcripts

ENSMUST00000043082	ENSMUSP00000043286
ENSMUST00000122902	ENSMUSP00000120877
ENSMUST00000125757	ENSMUSP00000117126
ENSMUST00000143771	ENSMUSP00000122560
ENSMUST00000156082	ENSMUSP00000116922

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0005179	hormone activity
GO:0005488	binding
GO:0047499	calcium-independent phospholipase A2 activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0008152	metabolic process
GO:0008219	cell death
GO:0019369	arachidonic acid metabolic process
GO:0034638	phosphatidylcholine catabolic process
GO:0043651	linoleic acid metabolic process
GO:0046338	phosphatidylethanolamine catabolic process
GO:0050482	arachidonic acid secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005622	intracellular
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm