InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hist1h3a

Summary

InnateDB Protein

IDBP-137210.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hist1h3a

Protein Name

histone cluster 1, H3a

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089293

InnateDB Gene

IDBG-137208 (Hist1h3a)

Protein Structure

UniProt Annotation

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006334	nucleosome assembly
GO:0006335	DNA replication-dependent nucleosome assembly
GO:0060968	regulation of gene silencing

Cellular Component

GO:0000228	nuclear chromosome
GO:0000786	nucleosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016020	membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome